About CADASIL Our Program CADASIL studies at the Memory & Aging Program Other CADASIL research How to support CADASIL research About living with CADASIL CADASIL research areas    


CADASIL RESEARCH:
OTHER RESEARCH AREAS

Cognition
Buffon F, Porcher R, Hernandez K, Kurtz A, Pointeau S, Vahedi K, Bousser MG, Chabriat H. Cognitive profile in CADASIL. J Neurol Neurosurg Psychiatry. 2006;77:175-80.
Abstract

O'Sullivan M, Barrick TR, Morris RG, Clark CA, Markus HS. Damage within a network of white matter regions underlies executive dysfunction in CADASIL. Neurology. 2005;65:1584-90.
Abstract

Amberla K, Waljas M, Tuominen S, Almkvist O, Poyhonen M, Tuisku S, Kalimo H, Viitanen M. Insidious cognitive decline in CADASIL. Stroke. 2004 Jul;35(7):1598-602.
Abstract   Free Full Text Article

Harris JG, Filley CM. CADASIL: neuropsychological findings in three generations of an affected family. J Int Neuropsychol Soc. 2001 Sep;7(6):768-74.
Abstract

Bruening R, Dichgans M, Berchtenbreiter C, Yousry T, Seelos KC, Wu RH, Mayer M, Brix G, Reiser M. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance. AJNR Am J Neuroradiol. 2001 Aug;22(7):1268-74.
Abstract  Free Full Text Article


Filley CM, Thompson LL, Sze CI, Simon JA, Paskavitz JF, Kleinschmidt-DeMasters BK. White matter dementia in CADASIL. J Neurol Sci. 1999 Mar 1;163(2):163-7.
Abstract


Dichgans M, Filippi M, Bruning R, Iannucci G, Berchtenbreiter C, Minicucci L, Uttner I, Crispin A, Ludwig H, Gasser T, Yousry TA. Quantitative MRI in CADASIL: correlation with disability and cognitive performance. Neurology. 1999 Apr 22;52(7):1361-7.
Abstract


Trojano L, Ragno M, Manca A, Caruso G. A kindred affected by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). A 2-year neuropsychological follow-up. J Neurol. 1998 Apr;245(4):217-22.
Abstract


Adair JC, Hart BL, Kornfeld M, Graham GD, Swanda RM, Ptacek LJ, Davis LE. Autosomal dominant cerebral arteriopathy: neuropsychiatric syndrome in a family. Neuropsychiatry Neuropsychol Behav Neurol. 1998 Jan;11(1):31-9.
Abstract


Retinal Involvement
Rufa A, Malandrini A, Dotti MT, Berti G, Salvadori C, Federico A. Typical pathological changes of CADASIL in the optic nerve. Neurol Sci. 2005 Oct;26(4):271-4.
Abstract


Rufa A, De Stefano N, Dotti MT, Bianchi S, Sicurelli F, Stromillo ML, D'Aniello B, Federico A. Acute unilateral visual loss as the first symptom of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arch Neurol. 2004 Apr;61(4):577-80.
Abstract

Haritoglou C, Rudolph G, Hoops JP, Opherk C, Kampik A, Dichgans M. Retinal vascular abnormalities in CADASIL. Neurology. 2004 Apr 13;62(7):1202-5.
Abstract

Harju M, Tuominen S, Summanen P, Viitanen M, Poyhonen M, Nikoskelainen E, Kalimo H, Kivela T. Scanning laser Doppler flowmetry shows reduced retinal capillary blood flow in CADASIL. Stroke. 2004 Nov;35(11):2449-52.
Abstract   Free Full Text Article

Rufa A, Dotti MT, Frezzotti P, De Stefano N, Caporossi A, Federico A. Hemodynamic evaluation of the optic nerve head in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arch Neurol. 2004 Aug;61(8):1230-3.
Abstract

Haritoglou C, Hoops JP, Stefani FH, Mehraein P, Kampik A, Dichgans M. Histopathological abnormalities in ocular blood vessels of CADASIL patients. Am J Ophthalmol. 2004 Aug;138(2):302-5.
Abstract

Cumurciuc R, Massin P, Paques M, Krisovic V, Gaudric A, Bousser MG, Chabriat H. Retinal abnormalities in CADASIL: a retrospective study of 18 patients. J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):1058-60.
Abstract   Free Full Text Article


Ravaglia S, Costa A, Santorelli FM, Nappi G, Moglia A. Retinal migraine as unusual feature of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Cephalalgia. 2004 Jan;24(1):74-7.
Abstract

Parisi V, Pierelli F, Fattapposta F, Bianco F, Parisi L, Restuccia R, Malandrini A, Ferrari M, Carrera P. Early visual function impairment in CADASIL. Neurology. 2003 Jun 24;60(12):2008-10.
Abstract

Robinson W, Galetta SL, McCluskey L, Forman MS, Balcer LJ. Retinal findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil). Surv Ophthalmol. 2001 Mar-Apr;45(5):445-8.
Abstract


Animal Models
Lundkvist J, Zhu S, Hansson EM, Schweinhardt P, Miao Q, Beatus P, Dannaeus K, Karlstrom H, Johansson CB, Viitanen M, Rozell B, Spenger C, Mohammed A, Kalimo H, Lendahl U. Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype. Genesis. 2005 Jan;41(1):13-22.
Abstract


Dubroca C, Lacombe P, Domenga V, Maciazek J, Levy B, Tournier-Lasserve E, Joutel A, Henrion D. Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. Stroke. 2005 Jan;36(1):113-7.
Abstract   Free Full Text Article


Costa RM, Honjo T, Silva AJ. Learning and memory deficits in Notch mutant mice. Curr Biol. 2003 Aug 5;13(15):1348-54
Abstract


Ruchoux MM, Domenga V, Brulin P, Maciazek J, Limol S, Tournier-Lasserve E, Joutel A. Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Am J Pathol. 2003 Jan;162(1):329-42.
Abstract  Free Full Text Article

Prakash N, Hansson E, Betsholtz C, Mitsiadis T, Lendahl U. Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL. Exp Cell Res. 2002 Aug 1;278(1):31-44.
Abstract

Fryxell KJ, Soderlund M, Jordan TV. An animal model for the molecular genetics of CADASIL. (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). Stroke. 2001 Jan;32(1):6-11.
Abstract   Free Full Text Article


Prevalence
Razvi SS, Davidson R, Bone I, Muir KW. The prevalence of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) in the west of Scotland. J Neurol Neurosurg Psychiatry. 2005 May;76(5):739-41.
Abstract

Gladstone JP, Dodick DW. Migraine and cerebral white matter lesions: when to suspect cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Neurologist. 2005 Jan;11(1):19-29.
Abstract


Dong Y, Hassan A, Zhang Z, Huber D, Dalageorgou C, Markus HS. Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosis. Stroke. 2003 Jan;34(1):203-5.
Abstract   Free Full Text Article

Uchino M, Hirano T, Uyama E, Hashimoto Y. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and CADASIL-like disorders in Japan. Ann N Y Acad Sci. 2002 Nov;977:273-8.
Abstract

Markus HS, Martin RJ, Simpson MA, Dong YB, Ali N, Crosby AH, Powell JF. Diagnostic strategies in CADASIL. Neurology. 2002 Oct 22;59(8):1134-8.
Abstract

Other
Schroder JM, Zuchner S, Dichgans M, Nagy Z, Molnar MJ. Peripheral nerve and skeletal muscle involvement in CADASIL. Acta Neuropathol (Berl). 2005;110:587-99.
Abstract

Milunsky A, Konialis C, Shim SH, Maher TA, Spengos K, Ito M, Pangalos C. The prenatal diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) by mutation analysis. Prenat Diagn. 2005;25:1057-8.
Abstract

Rufa A, Dotti MT, Franchi M, Stromillo ML, Cevenini G, Bianchi S, De Stefano N, Federico A. Systemic blood pressure profile in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Stroke. 2005;36:2554-8.
Abstract

Razvi SS, Davidson R, Bone I, Muir KW. Is inadequate family history a barrier to diagnosis in CADASIL? Acta Neurol Scand. 2005 Nov;112(5):323-6.
Abstract

Roine S, Poyhonen M, Timonen S, Tuisku S, Marttila R, Sulkava R, Kalimo H, Viitanen M. Neurologic symptoms are common during gestation and puerperium in CADASIL. Neurology. 2005 Apr 26;64(8):1441-3.
Abstract

Sicurelli F, Dotti MT, De Stefano N, Malandrini A, Mondelli M, Bianchi S, Federico A. Peripheral neuropathy in CADASIL. J Neurol. 2005 Oct;252(10):1206-9.
Abstract

Lesnik Oberstein SA, Jukema JW, Van Duinen SG, Macfarlane PW, van Houwelingen HC, Breuning MH, Ferrari MD, Haan J. Myocardial infarction in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Medicine (Baltimore). 2003 Jul;82(4):251-6.
Abstract

Lesnik Oberstein SA, van Duinen SG, van den Boom R, Maat-Schieman ML, van Buchem MA, van Houwelingen HC, Hegeman-Kleinn IM, Ferrari MD, Breuning MH, Haan J. Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. Acta Neuropathol (Berl). 2003 Aug;106(2):107-11.
Abstract

Lesnik Oberstein SA, van den Boom R, Middelkoop HA, Ferrari MD, Knaap YM, van Houwelingen HC, Breuning MH, van Buchem MA, Haan J. Incipient CADASIL. Arch Neurol. 2003 May;60(5):707-12.
Abstract

Schon F, Martin RJ, Prevett M, Clough C, Enevoldson TP, Markus HS. "CADASIL coma": an underdiagnosed acute encephalopathy. J Neurol Neurosurg Psychiatry. 2003 Feb;74(2):249-52.
Abstract  Free Full Text Article

Flemming KD, Nguyen TT, Abu-Lebdeh HS, Parisi JE, Wiebers DO, Sicks JD, O'Fallon WM, Petty GW. Hyperhomocysteinemia in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Mayo Clin Proc. 2001 Dec;76(12):1213-8.
Abstract

Manabe Y, Murakami T, Iwatsuki K, Narai H, Warita H, Hayashi T, Shoji M, Imai Y, Abe K. Nocturnal blood pressure dip in CADASIL. J Neurol Sci. 2001 Dec 15;193(1):13-6.
Abstract

Chuah TL, Tan SM, Flanagan S, Hyland V, Sullivan AA, Henderson R, MacMillan J, Lander C. CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy): an Australian perspective. J Clin Neurosci. 2001 Sep;8(5):404-6.
Abstract

Parisi V, Pierelli F, Malandrini A, Carrera P, Olzi D, Gregori D, Restuccia R, Parisi L, Fattapposta F. Visual electrophysiological responses in subjects with cerebral autosomal arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Clin Neurophysiol. 2000 Sep;111(9):1582-8.
Abstract

Unlu M, de Lange RP, de Silva R, Kalaria R, St Clair D. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry. Neurosci Lett. 2000 Mar 24;282(3):149-52.
Abstract

Dichgans M, Wick M, Gasser T. Cerebrospinal fluid findings in CADASIL. Neurology. 1999 Jul 13;53(1):233.
Abstract

 

Memory and Aging Program
Butler Hospital
345 Blackstone Blvd.
Providence, RI 02906


401-455-6403
Fax: 401-455-6405
memorydisorder.org

 

 

Website: Thea Brennan-Krohn
email: theabk@yahoo.com