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CLINICAL TRIALS AND RESEARCH

New treatments for CADASIL can only come about through a more thorough knowledge of the disease process. Our research program is dedicated to using the latest scientific techniques to understand the pathway leading from the genetic mutation to the symptoms of the disease.

Our research team includes faculty from the Brown Departments of Neurology, Psychiatry, Pathology, Molecular Biology, Diagnostic Imaging, Engineering, and Computer Science. Our CADASIL research focuses on genetics, neuropathology, brain imaging, and clinical trials. Our analysis of genetic mutations from over 10,000 people tested for CADASIL has led to the discovery of more than 119 new mutations. Using tissue from our CADASIL brain bank, we have been studying the role of the NOTCH3 gene in the deterioration of small blood vessels in the brain. We are also using an advanced MRI technique called diffusion-tensor imaging (DTI) to evaluate the areas of the brain affected by CADASIL. This year we will be testing a new MRI technique for visualizing the earliest brain changes in CADASIL. Working closely with CADASIL researchers around the world we played a leading role in developing and conducting the first medication trial for CADASIL.

Memory and Aging Program
Butler Hospital
345 Blackstone Blvd.
Providence, RI 02906


401-455-6403
Fax: 401-455-6405
memorydisorder.org

 

 

Website: Thea Brennan-Krohn
email: theabk@yahoo.com