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Butler Hospital
 
Memory and Aging Program
Dominantly Inherited Alzheimer's Network

memory-and-aging

What is the DIAN Study?

This is a longitudinal, observational study for individuals in ADAD families. Participants will visit Butler Hospital every other year for memory testing, brain scans, and laboratory procedures. During intervening years, a research coordinator will conduct an assessment over the phone  

What is the Purpose of the DIAN Study? 

DIAN is an international research partnership of leading scientists determined to understand a rare, early onset form of Alzheimer’s disease caused by a genetic mutation in one of three genes. Autosomal Dominant Alzheimer’s disease (ADAD) typically causes memory loss and dementia in the 30’s to 50’s and has a strong family history with approximately 50% of descendants being affected by the disease. ADAD is very rare as it makes up only 1% of the total cases of Alzheimer’s disease. Understanding this form of early, familial Alzheimer's disease may provide clues to decoding other dementias and may aide in developing dementia treatments. 

Eligibility 

DIAN is currently enrolling study participants who are biological adult children of a parent who carries a genetic mutation known to cause a rare, early onset form of Alzheimer’s disease. Study participants must be younger than the age at which their parent began displaying Alzheimer’s symptoms. Participants may or may not carry the gene themselves and may or may not have disease symptoms.

If you are interested in learning more about the DIAN study, please call (401) 455-6403 or send an e-mail to: memory@butler.org.

For information on other current research studies at Butler Hospital please click here.

More Information on the Dominantly Inherited Alzheimer’s Network

Does your family have one of the three known mutations for Alzheimer’s disease? Or, does your family have three generations of Alzheimer’s disease that starts younger than age 60? If so, join the DIAN Expanded Registry and learn about current and future research opportunities.

You can visit the DIAN website to learn more about the research they are doing. You may also download the DIAN-TU study brochure 

You can also learn more about DIAN TU, an investigational drug trial for those at risk for autosomal dominate Alzheimer’s disease.

DIAN Press Coverage

The research being conducted by the DIAN group has received world-wide attention and several research articles have been written by the study investigators. Some highlights include the following, all of which you are welcome to view and read:  

2016 DIAD Family Conference video, Too Young To Forget 

Watch a video about living with Alzheimer’s at age 47  

This article was published in the Foster’s Daily Democrat and shares the story of a DIAN TU family speaking out about their struggles with Alzheimer’s disease  

This article published in the Boston Globe focuses on a DIAN TU couple educating others about early-onset Alzheimer’s disease 

This research article on Dominantly Inherited Alzheimer’s Disease, (lead author Randall Bateman, MD) was published in the New England Journal of Medicine in 2012 

You can also visit the DIAN TU website for more recent news articles.

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