This is a longitudinal, observational study for individuals in ADAD families. Participants will visit Butler Hospital every other year for memory testing, brain scans, and laboratory procedures. During intervening years, a research coordinator will conduct an assessment over the phone.What is the Purpose of the DIAN Study?
DIAN is an international research partnership of leading scientists determined to understand a rare, early onset form of Alzheimer’s disease caused by a genetic mutation in one of three genes. Autosomal Dominant Alzheimer’s disease (ADAD) typically causes memory loss and dementia in the 30’s to 50’s and has a strong family history with approximately 50 percent of descendants being affected by the disease. ADAD is very rare as it makes up only 1 percent of the total cases of Alzheimer’s disease. Understanding this form of early, familial Alzheimer's disease may provide clues to decoding other dementias and may aide in developing dementia treatments.Eligibility
DIAN is currently enrolling study participants who are biological adult children of a parent who carries a genetic mutation known to cause a rare, early onset form of Alzheimer’s disease. Study participants must be younger than the age at which their parent began displaying Alzheimer’s symptoms. Participants may or may not carry the gene themselves and may or may not have disease symptoms.
If you are interested in learning more about the DIAN study, please call (401) 455-6403 or send an email to: firstname.lastname@example.org.
More information on other current research studies at Butler Hospital.More Information on the Dominantly Inherited Alzheimer’s Network
Does your family have one of the three known mutations for Alzheimer’s disease? Or, does your family have three generations of Alzheimer’s disease that starts younger than age 60? If so, join the DIAN Expanded Registry and learn about current and future research opportunities.
You can visit the DIAN website to learn more about the research they are doing.
You can also learn more about DIAN-TU, an investigational drug trial for those at risk for autosomal dominate Alzheimer’s disease.DIAN Press Coverage
The research being conducted by the DIAN group has received
world-wide attention and several research articles have been written by
the study investigators. Some highlights include the following.
What is the DIAN Trials Unit?
An informational video describing the DIAN Trials Unit based at the Washington University School of Medicine in St. Louis. They focus on developing and implementing clinical trials for people who carry genes that are known to cause an early onset form of Alzheimer’s disease.
Too Young To Forget
2016 DIAD Family Conference video,
Alzheimer’s at age 47
Watch a video about living with Alzheimer’s at age 47.
Family speaking out about their struggles with Alzheimer’s disease
This article was published in the Foster’s Daily Democrat.
Educating others about early-onset Alzheimer’s disease
This article published in the Boston Globe focuses on a DIAN TU couple.
Research article on Dominantly Inherited Alzheimer’s Disease,
Published in the New England Journal of Medicine in 2012 (lead author Randall Bateman, MD).
You can also visit the DIAN TU website for more recent news articles.