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Memory and Aging Program
Study - Dominantly Inherited Alzheimer's Network Trial (DIAN-TU)

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU)

What is the Purpose of the DIAN Study?

The purpose of this study is to assess the safety, tolerability, biomarker, and cognitive efficacy of gantenerumab and solanezumab in subjects who are known to have an Alzheimer's disease-causing mutation by determining if treatment with the study drug improves cognitive outcomes and disease-related biomarkers. Gantenerumab and solanezumab are antibodies, each having a unique approach to counter the toxic effects of amyloid beta, the main ingredient of brain plaques found in Alzheimer’s patients.


The study is ongoing at the Memory and Aging Clinic at Butler Hospital, but is no longer enrolling subjects.

More Information on the Dominantly Inherited Alzheimer’s Network

Does your family have one of the three known mutations for Alzheimer’s disease? Or, does your family have three generations of Alzheimer’s disease that starts younger than age 60? If so, join the DIAN Expanded Registry and learn about current and future research opportunities.

You can visit the DIAN-TU website to learn more about the research they are doing. You may also download the DIAN-TU study brochure.

You can also learn more about DIAN Observational, a non-drug study for children of those with autosomal dominate Alzheimer’s disease.

DIAN Press Coverage

The research being conducted by the DIAN group has received world-wide attention and several research articles have been written by the study investigators. Some highlights include the following, all of which you are welcome to view and read:

2016 DIAD Family Conference video, Too Young To Forget

This article was published in the Foster’s Daily Democrat and shares the story of a DIAN TU family speaking out about their struggles with Alzheimer’s disease

This article published in the Boston Globe focuses on a DIAN TU couple educating others about early-onset Alzheimer’s disease

This research article on Dominantly Inherited Alzheimer’s Disease, (lead author Randall Bateman, MD) was published in the New England Journal of Medicine in 2012

You can also visit the DIAN TU website for more recent news articles.

More information on other current research studies at Butler Hospital

Alzheimers Research Studies Butler Hospital, Providence, Rhode Island
Care New England
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