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Butler Hospital
Butler Hospital

Testosterone Antidepressant Augmentation Research Study

Butler Hospital's Mood Disorders Research Program (MDRP) is currently enrolling adult women with depression, ages 21-65, in a new clinical research trial. If you are a woman struggling with depression, taking an antidepressant and still feeling down, feeling fatigue, or low sex drive, you may be eligible to participate in a study investigating a natural hormonal treatment for depression.

The Testosterone Antidepressant Augmentation Clinical Trial for depression investigates the use of low-dose testosterone cream (applied to skin daily as an "add-on" treatment) when a woman's depression medications have not produced full relief from symptoms. Testosterone is not just a men's hormone. Low concentrations of testosterone circulate in female bodies, too. Testosterone impacts the brain and is important to women's health.

Study participants will be randomly assigned to receive an active or placebo cream, while continuing on a stable dose of a their primary antidepressants.

  • The study involves six visits to the MDRP research clinic on the Butler Hospital campus over an eight-week period.
  • Compensation up to $125 is available for eligible subjects who receive the study medication.


Adult women with depression, ages 21-65.

If you are interested in learning more about the Testosterone Antidepressant Augmentation research study, please call (401) 455-6537 or fill out the following form:

Please provide your name, telephone number, and a good time to reach you in the boxes below. Please do not include any other information. A member of the research team will contact you soon.

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