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Butler Hospital
Butler Hospital

TOPS Study

Have you ever wondered if you could control your OCD symptoms without the help of medications?

If so, the TOPS study might be right for you. Though serotonin reuptake inhibitors (SRIs) may help many people manage OCD symptoms, there are a variety of reasons individuals may like to discontinue the use of this medication. Our patients tell us some of these reasons include:

  • Sexual side effects.
  • Weight gain.
  • Cost.
  • A desire to see if they can stay well off medication.
  • Pregnancy or the desire to become pregnant.

Our past research shows us that many patients come off SRIs with little impact on their symptoms. We are interested in learning if our program can help patients safely and successfully accomplish this, by using a slow taper design and by monitoring patients' symptoms weekly throughout the treatment.

What is the Purpose of the TOPS Study?

The TOPS Study evaluates two supportive programs designed to help individuals with obsessive compulsive disorder (OCD) symptoms safely come off long-term medication frequently prescribed for OCD.

In this study we focus on one type of medication, serotonin reuptake inhibitors (SRIs), which include: Anafranil (clomipramine), Prozac (fluoxetine), Paxil (paroxetine), Lexapro (escitalopram), Celexa (citalopram), Luvox (fluvoxamine), Zoloft (sertraline), Effexor (venlafaxine), and Cymbalta (duloxetine).


Adults with OCD who wish to stop taking long-term (2 years or more) SRI medication may be eligible to participate.


Participation in TOPS involves an initial screening appointment to ensure eligibility that includes completion of interviews and questionnaires. Eligible individuals are then randomly assigned (by chance) to one of two 22-week programs using different techniques to help people come off medication.

All study participants will receive:

  • A comprehensive assessment of their symptoms.
  • One of two 22-week programs designed to support individuals coming off SRI medication.
  • Seven biweekly medication management sessions with an experienced study psychiatrist.
  • Compensation for time spent completing study assessments (up to $100 for full participation).

If you are interested in learning more about the TOPS study, please contact Maggie Peebles-Dorin at (401) 455-6243 or fill out the form below and a staff member will contact you.  Participation is voluntary. All information gathered will be treated as confidential.

(please specify am or pm)

  TOPS Study FAQ
Want to learn more about the TOPS Study for OCD? Visit our TOPS frequently asked questions page.
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