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What is the Study?

A 12-month double-blind, randomized, controlled feasibility study to evaluate the safety, efficacy and tolerability of deep brain stimulation of the fornix (DBS-f) in patients with mild probable Alzheimer’s disease.

What is the Purpose of Deep Brain Stimulation (DBS)?

DBS is often described as a “pacemaker for the brain” as it uses an implanted device to electronically stimulate the brain. In this study, a pacemaker-like device is implanted beneath the skin in the patient’s chest to deliver electrical pulses directly to the part of the brain that plays a central role in memory. In this double blind clinical trial, all participants will have the device implanted. Half of the subjects will have the device activated in the first year, and all the subjects will receive active stimulation in the second year of the study.


The population will consist of persons ages 55-80, living at home with an available caregiver. In good general health, on stable dose of memory medicine for two months.

If you are interested in learning more about the DBS study, please call (401) 455-6403 or email Diane Monast, RN, MSN at

More information on other current research studies at Butler Hospital.

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