Project MOM (Modulating OCD in Mothers)

Study Information:

Continuous Theta Burst Stimulation as a Novel Treatment for Postpartum Obsessive Compulsive Disorder 

Study Information:

The goal of this study is to find out how non-invasive brain stimulation, specifically Transcranial Magnetic Stimulation (TMS), effects obsessive-compulsive disorder (OCD) symptoms in postpartum women. The postpartum period can increase the risk of developing OCD. Research shows that 2–24% of women may develop new OCD symptoms after giving birth, and 8–70% of women with a history of OCD may experience a worsening of symptoms during this time. TMS is an FDA-cleared treatment for OCD that is considered safe for breastfeeding mothers, making it a potential alternative to medications. Accelerated TMS protocols may help reduce OCD symptoms more quickly during this critical period.

Participants in this study will receive 10 days of an experimental TMS protocol. Participants must also be willing to undergo brain imaging (Magnetic Resonance Imaging, or MRI) before and after they receive TMS. The main benefits of the study are to help researchers develop better interventions for OCD in the postpartum period. You may or may not see improvement in your OCD symptoms if you participate in this study.

Eligibility Criteria 

You may quality if you:

• Are between the ages of 18-45
• Have OCD symptoms that began or worsened within 12 months after childbirth
• Are either on a stable OCD medication dose for at least 8 weeks or not taking medication.
• Are in psychotherapy only if it began 8+ weeks before the study and continues throughout
• Are in good medical health (chronic medical conditions must be stable)
• Do not have a personal history of a psychosis, bipolar disorder, seizures, neurologic conditions, or traumatic brain injury
• Did not have pre-eclampsia in your most recent pregnancy (if less than 8 weeks postpartum)
• Are not currently pregnant
• Do not have metal implants that prevent MRI scanning
• Can understand and read English well enough to complete study procedures and provide informed consent

Compensation / Reimbursement

Up to $1,950 in the form of check or gift card.