What is the U.S. POINTER study?

The U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a Phase 3, two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target multiple risk factors protect cognitive function in older adults at increased risk for cognitive decline. A recent study in Finland (the FINGER trial) found that a combination of physical and cognitive exercise, diet, and social activity protected cognitive function in healthy older adults who were at increased risk of significant memory loss. U.S. POINTER is the first such study to be conducted in a large group of Americans. Approximately 2,000 participants will be enrolled across five study sites in the United States.


What is the purpose of the U.S. POINTER study?

The purpose of this study is to see if lifestyle changes, adapted to American culture and delivered in the community, can protect memory and thinking (cognition) as people age. Two lifestyle interventions will be compared, which vary in format. Eligible participants will be randomly assigned to one of the groups to evaluate whether cognitive benefits from a structured program differ from a self-guided program.



This study is for men and women aged 60 – 79 who are not regular exercisers (generally less than 3 times per week) and who may have risks for memory loss in the future such as a family history of memory problems or slightly high blood pressure, cholesterol or blood sugar.


Interested participants can learn more about the U.S. POINTER study by contacting the Memory and Aging Outreach Team at 401-455-6402 or by sending an email to memory@butler.org.

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Butler Hospital

Area of Study
Memory and Aging