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Center of Biomedical Research Excellence (COBRE)

Center for Neuromodulation (CCN)

A 2018 award from the National Institute of General Medical Sciences (NIGMS) to Butler Hospital established the Center of Biomedical Research Excellence (COBRE) on Neuromodulation, or CCN. The mission of Butler’s CCN is to support innovative clinical research in neuromodulation (brain stimulation) and the career development of investigators in this field. The work couples brain stimulation methods with readouts of brain activity (e.g., using various neuroimaging, behavioral, and physiological assessment methods) in clinical or clinically-relevant populations. The CCN provides a platform for exchange of scientific insights and technical skills, and mentoring so project leaders can move towards scientific independence. A robust pilot project award program provides support for new proposals and scientists who stand to contribute to a sustainable pipeline of researchers in clinical neuromodulation. The CCN focuses on neuropsychiatric illness with the guiding principle that for noninvasive brain stimulation to gain clinical efficacy and implementation, it is imperative to better characterize clinically-relevant target circuits and mechanisms of action.


The CCN includes (1) a Design and Analysis Core (DAC) to support rigorous and innovative experimental design and data analytic strategies; (2) a Neuromodulation and Neuroimaging Core (NNC) to facilitate the acquisition and processing of high-quality data using noninvasive neurostimulation and neuroimaging methods; (3) an Administrative Core to oversee and coordinate activities to propel development of investigators towards independence. The CCN will identify and promote the success of new neuromodulation scientists through recruitment of new PLs and through its Pilot Project program, integrating the resources of the DAC and NNC.