A 2018 award from the National Institute of General Medical Sciences (NIGMS) to Butler Hospital established the Center of Biomedical Research Excellence (COBRE) on Neuromodulation or CCN. The mission of Butler’s CCN is to support innovative clinical research in neuromodulation (brain stimulation) and the career development of investigators in this field. The work couples brain stimulation methods with readouts of brain activity (e.g., using various neuroimaging, behavioral, and physiological assessment methods) in clinical or clinically-relevant populations. The CCN provides a platform for exchange of scientific insights and technical skills and mentoring so project leaders can move towards scientific independence. A robust pilot project award program provides support for new proposals and scientists who stand to contribute to a sustainable pipeline of researchers in clinical neuromodulation. The CCN focuses on neuropsychiatric illness with the guiding principle that for noninvasive brain stimulation to gain clinical efficacy and implementation, it is imperative to better characterize clinically-relevant target circuits and mechanisms of action.
The CCN includes (1) a Design and Analysis Core (DAC) to support rigorous and innovative experimental design and data analytic strategies; (2) a Neuromodulation and Neuroimaging Core (NNC) to facilitate the acquisition and processing of high-quality data using noninvasive neurostimulation and neuroimaging methods; (3) an Administrative Core to oversee and coordinate activities to propel the development of investigators towards independence. The CCN will identify and promote the success of new neuromodulation scientists through the recruitment of new PLs and through its Pilot Project program, integrating the resources of the DAC and NNC.
The CCN Administrative Core, develops design/statistical, neuroimaging, and brain stimulation resources focusing particularly on COBRE projects and new pilot research. The CCN Administrative Core works closely with our partners. These include IDeA Networks of Biomedical Research Excellence (INBRE) Centers and IDeA-Clinical and Translational (CTR) programs in Rhode Island, collaborating entities at/affiliated with Brown University including the Brown Department of Psychiatry and Human Behavior (DPHB), Carney Institute for Brain Science, COBRE Center for Central Nervous System Function (CCNSF), Advance Clinical and Translational Research (Advance-CTR) and the Providence VA Medical Center for Neurorestoration and Neurotechnology (CfNN).
Dr. Benjamin Greenberg has a BA in psychology from Amherst College, a PhD in neurosciences from UC San Diego, and an MD from the University of Miami, with psychiatry residency at Johns Hopkins. He then led adult OCD research at NIMH, where he performed the first transcranial magnetic stimulation (TMS) study in that illness. At Butler Hospital and Brown since 2000, he has focused on invasive neurosurgeries including ventral capsulotomy and deep brain stimulation (DBS). FDA humanitarian approval of DBS for intractable OCD in 2009 was based on that work. His NIH funding has included R21, R01, U01, P50, and P20 grants. He has a secondary focus in psychiatric genetics. As a clinical psychiatrist, he has treated OCD for thirty years; and over the past five years has also treated PTSD, he previously led Butler outpatient services. He currently directs the COBRE Center for Neuromodulation at Butler Hospital and co-directs the Center for Neuromodulation and Neurotechnology (CfNN) at the Providence VAMC (PVAMC), in both roles focusing on noninvasive brain stimulation.
Linda L. Carpenter, MD is a Professor of Psychiatry in the Alpert Medical School of Brown University and Chief of the Mood Disorders Program at Butler Hospital. She completed her undergraduate psychology degree at the University of Michigan, her MD from the University of Pennsylvania. She did an internship in internal medicine, psychiatry residency training, and a clinical neuroscience research fellowship all at Yale University. She joined the Brown Psychiatry faculty at Brown in 1997 and has continued her path as a physician-scientist investigating the neurobiology of, and new treatments for, major depression and other mood and anxiety disorders at Butler Hospital. She led a 10-year, federally funded translational research program focusing on the development of laboratory biomarkers signaling risk for mood/anxiety disorders, and understanding the impact of early life stress on adult biology. She has also conducted a number of randomized clinical trials sponsored by industry and NIH, investigating investigational drugs and devices for treating depression, including esketamine, Vagus Nerve Stimulation (VNS), Deep Brain Stimulation (DBS), Transcranial Magnetic Stimulation (TMS) and transcranial Direct Current Stimulation (tDCS). She is the founding Director of the Butler Hospital TMS Clinic and Neuromodulation Research Facility. Her lab evaluates new neurostimulation treatments and their mechanisms, using both EEG and fMRI. In addition to her role as Deputy Director of the Butler COBRE Center, she is Director of the Neuromodulation and Neuroimaging Core. She works with the COBRE Project Leaders, Brown trainees, and other Brown-affiliated research faculty who incorporate noninvasive brain stimulation techniques into their clinical mechanisms and therapeutics research. Dr. Carpenter also chairs the Butler Hospital Institutional Review Board (IRB).
Dr. Tyrka received her MD and PhD in medicine and psychology through a combined program at the University of Pennsylvania. She completed a psychiatry residency at Brown Medical School and further research training in clinical neuroscience at the Mood Disorders Research Program and Laboratory for Clinical Neuroscience at Butler Hospital and Brown University. Dr. Tyrka is Professor of Psychiatry and Human Behavior at Brown. She is the Director of Research at Butler Hospital and Director of the Laboratory for Clinical and Translational Neuroscience. Director of Research Training and PI of the NIMH-funded R25 Research Training Program in the Brown psychiatry residency program, Dr. Tyrka is dedicated to mentoring and training. Dr. Tyrka's program of research is focused on discovering the social, behavioral and molecular mechanisms of risk and resilience in children and adults with a history of early adversity and trauma. She Co-Directs the Brown Psychiatry Initiative on Stress, Trauma, and Resilience, and a postdoctoral T32 research training program on this topic. Dr. Tyrka is Associate Director of the Administrative Core, and leads the Mentorship Program of the Butler Hospital CCN.
Kristen Fortin-Ashburne obtained a BA in psychology (sociology minor) from the University of Massachusetts Dartmouth and MBA in Global Business Leadership (Organizational Leadership concentration) from Johnson & Wales University. She joined the CCN leadership team with over sixteen years’ experience in research, health care system administration, operations and project management. Prior to joining CCN, Ms. Fortin-Ashburne was Senior Clinical Research Technologist in Dr. Mary Carskadon’s E.P. Bradley Sleep Research Laboratory located on the Butler Hospital campus. Following her MBA, she was the clinical supervisor in the high-volume UMass Memorial Sleep Disorders Center. Later, she held the position of operations supervisor managing the overall business and academic operations of a large medical center in an underserved area, Tri River Family Health Center of the Blackstone Valley. In addition to CCN programmatic grant management, Ms. Fortin-Ashburne works closely with institutional senior leadership (notably our Hospital Advisory Committee) to streamline processes, enhance growth, and add efficiency to improve operations and quality of services.
Project EPIC: Brain Circuitry of inhibitory control in young adults: Modulation with tDCS
Dr. McLaughlin is Assistant Professor of Psychiatry and Human Behavior at the Alpert Medical School of Brown University and a neuropsychologist at Butler Hospital. She completed a PhD in clinical psychology at Suffolk University and then postdoctoral training in neuropsychology at Brown University and Butler Hospital, where she directs its psychiatric neurosurgery program. She has extensively studied prefrontal-subcortical functioning across neuropsychiatric disorders, with a more recent emphasis on the assessment of brain changes after neurocircuit-based interventions. She continues this line of research as a CCN Project Leader in COBRE, with a project investigating the inhibitory control (IC) network in young adults with deficits in ‘real-world’ IC (implicated in many neuropsychiatric illnesses); and assesses how a noninvasive method, high-definition-transcranial direct current stimulation (HD-tDCS) modulates MRI measures of functional connectivity within that network.
Project RISE: Effects of tDCS timing on safety memory in PTSD
Dr. van’t Wout-Frank is Assistant Professor of Psychiatry and Human Behavior at Alpert Medical School, Brown University. She completed a doctoral degree in the Netherlands - where she was born - in cognitive neuropsychiatry, focusing on emotion processing in schizophrenia and related disorders. Following her PhD, Dr. van’t Wout-Frank continued work on emotional and social cognition at the University of Arizona, and later Brown University, in postdoctoral research on decision making. At Brown she became particularly interested in using noninvasive brain stimulation to understand and modify negative emotions, such as fear, regret and pain, and has worked to develop neuromodulation to treat posttraumatic stress disorder, in collaboration with the Center for Neurorestoration and Neurotechnology at the Providence VA Medical Center. Her CCN project extends that work by testing how the timing of noninvasive tDCS in a fear extinction paradigm affects safety learning, safety memory, and MRI-measured brain activity in individuals with posttraumatic stress symptoms, knowledge important to optimizing clinical neuromodulation.
Project FLEX: Modulating prefrontal circuits underlying behavioral flexibility in OCD: a TMS study
Sarah Garnaat, PhD, is Assistant Professor of Psychiatry and Human Behavior at the Alpert Medical School of Brown University and a Research Psychologist at Butler Hospital. A licensed clinical psychologist and clinical researcher, she completed her doctoral training at the University of Houston and a T32 postdoctoral fellowship in treatment research at Brown University. Dr. Garnaat is an investigator in the Brown & Butler OCD Research Group and has expertise in the assessment and treatment of obsessive-compulsive disorder (OCD) and anxiety disorders. Her current research efforts focus on use of neuroscientific approaches to better understand the brain in OCD and inform development of novel treatments for OCD and anxiety disorders, as well as use of noninvasive neuromodulation to enhance behavioral interventions. The goal of her project is to investigate brain networks underlying difficulty with behavioral flexibility in OCD, using transcranial magnetic stimulation (TMS) as a probe of the system and fMRI to measure functional changes within related brain networks.
Our guiding scientific principle is that for the promise of neuromodulation therapies to be fully realized, it is critical to better characterizing their target circuits and mechanisms of action.
Our guiding organizational principle is to create structures and governance to propel promising junior investigators in this field towards independent scientific careers. This involves the following aims:
Implement our management plan and mentorship program to expand the group of clinical-translational researchers doing therapeutically relevant and mechanistically informative neuromodulation research in Rhode Island. We have developed research core resources for the RI scientific community. one to support research design and later data analysis and interpretation, and another to acquire neuromodulation and neuroimaging data using best practices. The administrative core oversees fiscal management, fosters CCN cohesion, and evaluates the Center’s overall progress.
Steven Burke, MBA, CFO, Butler Hospital, Care New England
Mary Marran OT MBA, Chair, COO, Butler Hospital, Care New England
Steven Brown, ITILv3, IT Site Manager Academic and Research, Care NewEngland
Guarav Choudhary MD, Providence VA Medical Center
John Davenport PhD, Brown University
James Padbury, MD, PhD, Women & Infants Hospital, Care New England
Lawrence Price MD, Brown University
Steve Rasmussen MD, Butler Hospital, Brown University
Erika Forbes, Ph.D, University of Pittsburgh
Mark George, MD, Medical University of South Carolina
Stephan Taylor, MD, EAC Chair, University of Michigan
Eric Wassermann, MD, National Institute of Neurological Disorders and Stroke
The COBRE Center for Neuromodulation aims to increase the quantity and quality of research in clinical neuromodulation (brain stimulation) in Rhode Island. One means of attaining this goal is identifying and nurturing talented young neuromodulation investigators or established investigators who want to create a new research line in the arena of neuromodulation. The Pilot Program supports the COBRE’s growth by encouraging additional scholarship in the COBREs thematic areas and developing potential new COBRE Project Leaders.
Our Center will award up to three pilot project awards annually, depending on available funding, for research related to Neuromodulation. Neuromodulation research encompasses the development of new brain stimulation targets, therapeutic interventions, or the use of neuromodulatory tools to otherwise understand and address neuropsychiatric disorders or their mechanisms. We aim to enable investigators to collect preliminary data in support of grant applications for independent external research funding, especially from the NIH. Pilot project leaders can take advantage of the COBRE CCN community to help guide their science and career development.
Pilot project leaders will have access to the COBRE’s three interdisciplinary cores. These cores will provide infrastructure, consultation, and additional support services to ensure the successful career development of the funded junior investigator and help them apply for external, independent funding. The three Cores include an Administrative Core, a Design and Analysis Core (DAC), and a Neuromodulation and Neuroimaging Core (NNC).
The Neuromodulation and Neuroimaging Core (NNC) facilitates the research goals of COBRE Project Leaders and pilot grant investigators, and benefits the broader neuromodulation research community by providing expert support, training, assistance, and advice to its constituents in the practical aspects of implementation, data collection, and project management related to neuroimaging and neurostimulation methods. The NNC addresses a critical need, namely, to provide Project Leaders with unique resources, skills, and support for using the best methods and practices surrounding neuroimaging and neuromodulation in clinical neuropsychiatric populations. The NNC provides key services for research projects and creates an enduring resource that offers neuromodulation researchers a series of educational seminars, hands-on workshops, and customized training opportunities, high-level consultative and medical input, and use of a specialty research facility at Butler Hospital with lab space, equipment, and medical support.
The Design and Analysis Core (DAC) provides experimental design, statistical support, and neuroimaging consultation services to COBRE Project Leaders and the broader scientific research community. DAC faculty are affiliated with the Quantitative Sciences Program (QSP) of the Departments of Psychiatry and Neurology at the Alpert Medical School of Brown University and the Center for Neurorestoration and Neurotechnology at Providence VA Medical Center. Core Leader Richard Jones, ScD is a psychiatric epidemiologist and methodologist and the director of the QSP. Core Co-Leader Jennifer Barredo, PhD is a neuroscientist with expertise in neuroimaging methodologies including advanced diffusion imaging, multimodal analysis, and machine learning. The DAC also maintains scientific computing resources and workflows available to COBRE project and pilot investigators, and sponsors educational seminars and workshops.
Quantitative Sciences Program of the Departments of Psychiatry and Neurology at the Alpert Medical School of Brown University and the Norman Prince Neurosciences Institute
Research reported in this website was supported by the National Institute of General Medical Science of the National Institutes of Health under grant number P20GM130452. If you have received funding, consultation, mentorship, research support services, materials, training, access to shared equipment and/or space from the COBRE Center for Neuromodulation Cores, please acknowledge the COBRE Center for Neuromodulation by using the following statement:
Grant citing in all abstracts (presentations), and publications by investigators: “Research reported in this publication was supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award Number P20GM130452, Center for Biomedical Research Excellence, Center for Neuromodulation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”
Core Facility users citing:
“Research was facilitated by the National Institute Of General Medical Sciences of the National Institutes of Health under Award Number P20GM130452, Center for Biomedical Research Excellence, Center for Neuromodulation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health”
Please also send the title of your presentation, and where and when you presented the work or the citation for your manuscript. COBRECCN@CareNE.org
This portion of our website is supported by the COBRE Center of Neuromodulation Funded by the National Institutes of Health grant number P20GM130452. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health
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