Research at Butler Hospital

The purpose of this research is to evaluate whether a take-home, self-administered, neurostimulation device called Relivion®DP is safe and helpful for reducing symptoms of Major Depressive Disorder (MDD). 

The purpose of this study is to look at how thoughts and emotions change during depression treatment. 

The purpose of this study is to understand whether esketamine effectively treats treatment-resistant depression (TRD) as a monotherapy. 

An observational study will evaluate the feasibility of using app-based brain games to assess cognitive function over several days using a smartphone.

An observational study aims to understand what changes to the retina can detect Alzheimer’s risk before memory symptoms occur.

A Phase III, double-blinded, placebo-controlled study with a treatment arm. Eligible participants will be randomly assigned to receive either the investigational medication, BAN2401, or placebo.

A 5 year observational study that requires participants to undergo a variety of exams to determine the relationships between various characteristics of the Alzheimer’s disease spectrum.

This is an observational study to learn more about assessing potential risk for developing Alzheimer’s disease (AD) using biomarker research.

A longitudinal, observational study for individuals in ADAD families. ADAD is a genetic mutation that typically causes memory loss and dementia in the 30s to 50s.

The purpose of the Janssen AuTonomy trial is to assess the ability of the investigational medication in slowing the cognitive decline in participants with Early AD, as well as its safety and tolerability.

An observational study exploring the development of early-onset Alzheimer’s disease and how it compares to the more common late-onset Alzheimer’s disease.

The purpose of this study is to look at the safety and tolerability of Emtricitabine (FTC, Emtriva©, Gilead) in treating participants with MCI or mild to moderate AD.

A two-year clinical trial to test whether lifestyle interventions that target multiple risk factors protect cognitive function in older adults at increased risk for cognitive decline.

A study for individuals in early recovery from opioid use and taking the medication buprenorphine (suboxone). Participants will engage in 5 sessions of active or placebo transcranial direct stimulation (tDCS) during the course of this 2-week study.

The goal of Project Start is to develop and evaluate different interventions aimed at increasing Disulfiram (Antabuse) medication adherence.

The purpose of this study is to better understand how the brain works to allow people with OCD to make decisions and accomplish goals.

We are looking for healthy individuals with no psychiatric diagnoses to help us study how the brain works as it makes decisions to accomplish a goal. 

Project PROVOC is a research study investigating differences in brain circuitry between people with OCD and those with either a specific phobia or no history of psychiatric diagnosis.

Project FLEX is a research study examining how the brain shifts back and forth between different demands, which may help researchers develop new treatment options for OCD. To do this, participants with and without OCD will be asked to engage in questionnaires, functional magnetic resonance imaging (fMRI) scans, and transcranial magnetic stimulation (TMS), a form of noninvasive brain stimulation.

Project FLEX is a research study examining how the brain shifts back and forth between different demands, which may help researchers develop new treatment options for OCD. To do this, participants with and without OCD will be asked to engage in questionnaires, functional magnetic resonance imaging (fMRI) scans, and transcranial magnetic stimulation (TMS), a form of noninvasive brain stimulation.

Project STIM is a research study testing how TMS may change brain activity and symptoms in people with OCD.

A study examining factors that may have influenced a decision whether or not to be vaccinated against COVID-19 while pregnant.

Determining whether TMS changes the brain through synaptic plasticity.

Research Investigating Stimulation for Extinction in PTSD.

We are looking for healthy volunteers with no psychiatric diagnoses to help us compare to those with Major Depressive Disorder.