Research at Butler Hospital

Our Research Programs

Affiliated with The Warren Alpert Medical School of Brown University, Butler Hospital’s clinical research trials provide valuable information on brain-based diseases. Through our research, new treatments are being discovered for diseases including depression and anxiety, obsessive-compulsive disorder (OCD), Alzheimer’s disease, Movement Disorders, such as Parkinson’s disease, and addictions.


Butler Hospital
345 Blackstone Blvd.
Providence, RI 02906

Center of Biomedical Research Excellence (COBRE)

A 2018 award from the National Institute of General Medical Sciences (NIGMS) to Butler Hospital established the Center of Biomedical Research Excellence (COBRE) on Neuromodulation, or CCN. 

Learn More About COBRE

Memory and Aging Program

An affiliate of The Warren Alpert Medical School of Brown University, MAP has a 20+ year history of excellence in clinical care, training, and cutting-edge research aimed at developing new and better ways to detect, treat, and someday even prevent Alzheimer’s.

Learn More About the Memory and Aging Program

Psychiatric Neurosurgery Program

Neurosurgical procedures can help patients suffering from treatment-resistant psychiatric and neurological conditions including OCD, depression, Tourette’s and movement disorders such as Parkinson’s disease.

Learn More About the Psychiatric Neurosurgery Program

Explore Our Current Studies

Learn more about Butler Hospital's research relating to mood disorders, obsessive-compulsive disorders, memory disorders, movement disorders as well as other studies researching aspects of mental health. Follow the links below to view current studies.

Mood Disorders

A Pilot Study of the Word-Sentence Association Paradigm for Non-Judgment (WSAP-NJ)

Complete a brief, one-time, online study to assess mood, mindfulness, and how you view yourself.


Researchers are producing a video series, called LifePlans, in which people with a history of suicidal thoughts or a suicide attempt share their experience of overcoming these problems.

TeenThrive: A Research Study

Researchers are conducting a study of a yoga program and a group therapy program for teens who are feeling stressed, down, or depressed.

Wellness for Two: Nurturing the Wellbeing of Mom and Baby
Seasonal Affective Disorder MRI Study

This brain imaging study is in collaboration with Brown University looking to compare different intensities of light and its effect on the brain of those with seasonal depression.

MRI Study With and Without Depression

Examining the impact of varying light intensities on the brain using MRI for individuals with and without depression.

Healthy Expectations (CLOSED)

Memory and Aging

DigiCog AD Study

An observational study will evaluate the feasibility of using app-based brain games to assess cognitive function over several days using a smartphone.

Atlas of Retinal Imaging in Alzheimer's (ARIAS)

An observational study aims to understand what changes to the retina can detect Alzheimer’s risk before memory symptoms occur.


A Phase III, double-blinded, placebo-controlled study with a treatment arm. Eligible participants will be randomly assigned to receive either the investigational medication, BAN2401, or placebo.


A two-year clinical trial to test whether lifestyle interventions that target multiple risk factors protect cognitive function in older adults at increased risk for cognitive decline.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI-3)

A 5 year observational study that requires participants to undergo a variety of exams to determine the relationships between various characteristics of the Alzheimer’s disease spectrum.

Longitudinal Early-onset Alzheimer’s Disease Study (LEADS)

An observational study exploring the development of early-onset Alzheimer’s disease and how it compares to the more common late-onset Alzheimer’s disease.

Dominantly Inherited Alzheimer's Network (DIAN)

A longitudinal, observational study for individuals in ADAD families. ADAD is a genetic mutation that typically causes memory loss and dementia in the 30s to 50s.



A study for individuals in early recovery from opioid use and taking the medication buprenorphine (suboxone). Participants will engage in 5 sessions of active or placebo transcranial direct stimulation (tDCS) during the course of this 2-week study.

Project BetterOFF (Closed)
Project Start

The goal of Project Start is to develop and evaluate different interventions aimed at increasing Disulfiram (Antabuse) medication adherence.

Obsessive Compulsive Disorder

Transcranial Magnetic Stimulation (TMS) for OCD

Project STIM is a research study testing how TMS may change brain activity and symptoms in people with OCD.

Project STIM for the Healthy Brain
Project FLEX: Studying the Flexible Brain
Project FLEX: Studying the Flexible Brain in OCD
Core Features


Project TIPS (TMS-Induced Plasticity of the Synapse)

Determining whether TMS changes the brain through synaptic plasticity.

Project EPIC
Project Rise in PTSD

Research Investigating Stimulation for Extinction in PTSD.