Research at Butler Hospital

The purpose of this research is to evaluate whether a take-home, self-administered, neurostimulation device called Relivion®DP is safe and helpful for reducing symptoms of Major Depressive Disorder (MDD). 

The purpose of this study is to understand whether esketamine effectively treats treatment-resistant depression (TRD) as a monotherapy. 

An observational study will evaluate the feasibility of using app-based brain games to assess cognitive function over several days using a smartphone.

An observational study aims to understand what changes to the retina can detect Alzheimer’s risk before memory symptoms occur.

A Phase III, double-blinded, placebo-controlled study with a treatment arm. Eligible participants will be randomly assigned to receive either the investigational medication, BAN2401, or placebo.

A two-year clinical trial to test whether lifestyle interventions that target multiple risk factors protect cognitive function in older adults at increased risk for cognitive decline.

A 5 year observational study that requires participants to undergo a variety of exams to determine the relationships between various characteristics of the Alzheimer’s disease spectrum.

An observational study exploring the development of early-onset Alzheimer’s disease and how it compares to the more common late-onset Alzheimer’s disease.

A longitudinal, observational study for individuals in ADAD families. ADAD is a genetic mutation that typically causes memory loss and dementia in the 30s to 50s.

The purpose of the Janssen AuTonomy trial is to assess the ability of the investigational medication in slowing the cognitive decline in participants with Early AD, as well as its safety and tolerability.

A study for individuals in early recovery from opioid use and taking the medication buprenorphine (suboxone). Participants will engage in 5 sessions of active or placebo transcranial direct stimulation (tDCS) during the course of this 2-week study.

The goal of Project Start is to develop and evaluate different interventions aimed at increasing Disulfiram (Antabuse) medication adherence.

Project PROVOC is a research study investigating differences in brain circuitry between people with OCD and those with either a specific phobia or no history of psychiatric diagnosis.

Project STIM is a research study testing how TMS may change brain activity and symptoms in people with OCD.

Project FLEX is a research study examining how the brain shifts back and forth between different demands, which may help researchers develop new treatment options for OCD. To do this, participants with and without OCD will be asked to engage in questionnaires, functional magnetic resonance imaging (fMRI) scans, and transcranial magnetic stimulation (TMS), a form of noninvasive brain stimulation.

Project FLEX is a research study examining how the brain shifts back and forth between different demands, which may help researchers develop new treatment options for OCD. To do this, participants with and without OCD will be asked to engage in questionnaires, functional magnetic resonance imaging (fMRI) scans, and transcranial magnetic stimulation (TMS), a form of noninvasive brain stimulation.

Determining whether TMS changes the brain through synaptic plasticity.

Research Investigating Stimulation for Extinction in PTSD.