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Aducanumab in Early Alzheimer's Disease (ENGAGE)  Memory Disorders
Study Type: Clinical
Study Ends On: Ongoing
The ENGAGE Study is a global study assessing the efficacy and safety of an investigational medication to determine whether it can slow the progression of symptoms in early Alzheimer’s disease.

ADvance Study (Closed)  Memory Disorders
Study Type: Clinical
Study Ends On: Ongoing
A 12-month double-blind, randomized, controlled feasibility study to evaluate the safety, efficacy and tolerability of deep brain stimulation of the fornix (DBS-f) in patients with mild probable Alzheimer’s disease.

CAD106 and BACE-1 Inhibitor (Generation)  Memory Disorders
Study Type: Clinical
Study Ends On: Ongoing
A five year study of more than 1,300 cognitively healthy adults, ages 60 to 75, at high risk of developing symptoms of Alzheimer’s because they inherited two copies of the apolipoprotein E (ApoE4) gene - one from each parent.

Core Features Study  Obsessive-Compulsive Disorders
Study Type: Clinical
Study Ends On: Ongoing
This study is to study brain connections and how the brain functions in people who suffer from obsessive compulsive disorder (OCD), anxiety, and hoarding.

Exploring the healthy brain  Obsessive-Compulsive Disorders
Study Type: Clinical
Study Ends On: Ongoing
In order to better understand and treat obsessive-compulsive disorder (OCD) Project STIM sets out to identify the differences in functionality between the brains of individuals who have OCD and those that do not (healthy participants).

Healthy Expectations  Mood Disorders
Study Type: Clinical
Study Ends On: Ongoing
Researchers at Butler and Women & Infants' Hospitals are conducting a study examining two prenatal programs to see whether they help improve mood and feelings of well-being during pregnancy.

Imaging Dementia Evidence for Amyloid Scanning (IDEAS) (CLOSED)  Memory Disorders
Study Type: Clinical
Study Ends On: Ongoing
The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) Study will determine the clinical usefulness on patient-oriented outcomes of a brain positron emission tomography (PET) scan that detects amyloid plaques, a core feature of Alzheimer’s disease.

Project BetterOFF  Addiction
Study Type: Clinical
Study Ends On: Ongoing
This study is designed to test the use of a smartphone app to help people transition off opioid medications, used either as part of medication assisted treatment for addiction or pain management.

Project FREE  Other
Study Type: Clinical
Study Ends On: Ongoing
Do you want to quit smoking and free yourself from cigarettes? Joining Project FREE may help you finally quit smoking for good!

Project LIFESTORIES  Mood Disorders
Study Type: Clinical
Study Ends On: Ongoing
Project LIFESTORIES is a research study that explores how, through video storytelling, people can learn from others who have been able to manage and even overcome their depression.

Project MOVE  Mood Disorders
Study Type: Clinical
Study Ends On: Ongoing
We’d like to introduce you to ways to improve both your physical and mental health. In our Project MOVE research study, we will help you get started with exercise.

Project STIM for OCD  Obsessive-Compulsive Disorders
Study Type: Clinical
Study Ends On: Ongoing
Changes in people with OCD through MRI scans done before and after a course of noninvasive brain stimulation (10 or more sessions)

Project THOUGHT  Addiction
Study Type: Clinical
Study Ends On: Ongoing
Project THOUGHT is a research study funded by the National Institutes of Health. We are testing whether the excitement of specific brain regions can change cravings for opioids in individuals who recently started Suboxone. Participation in Project THOUGHT would involve the following: questionnaires and interviews, 7 visits to Butler Hospital in Providence, RI and 2 brain scans.

Seasonal Affective Disorder MRI Study  Mood Disorders
Study Type: Clinical
Study Ends On: Ongoing
The purpose of this study is to understand how different intensities of light impact the brain in individuals with and without depression (seasonal and nonseasonal forms). Participation involves a screening assessment that lasts up to one hour and a single brain MRI scan procedure at the Brown MRF facility (within 1-2 weeks).

Tau PET Tracer Autopsy (Avid A16)  Memory Disorders
Study Type: Clinical
Study Ends On: Ongoing
This study is aimed at understanding the relationship between tau protein detected by PET scan and actual tau protein present in post-mortem brain tissue.

TeenThrive  Mood Disorders
Study Type: Clinical
Study Ends On: Ongoing

The Learning and Behavior Research Study  Other
Study Type: Clinical
Study Ends On: Ongoing
We’re conducting a research study to measure how different states of mental health effect impact behaviors and learning processes.

TIES Research Study for OCD  Obsessive-Compulsive Disorders
Study Type: Clinical
Study Ends On: Ongoing
TIES (Therapy Integrating Exposure and Stimulation) is a new study designed to help individuals with OCD who are looking for behavior therapy

TOPS  Obsessive-Compulsive Disorders
Study Type: Clinical
Study Ends On: Ongoing
Have you ever wondered if you could control your OCD symptoms without the help of medications?

Transcranial Direct Current Stimulation (tDCS) for Chronic Low Back Pain (CLOSED)  Other
Study Type: Clinical
Study Ends On: Ongoing
We are studying a new device for treating chronic low back pain (CLBP) and are enrolling adults age 18+ in a clinical research trial. If you have been diagnosed with CLBP by a physician for at least 6 months, have tried at least one physician-recommended pain medicine, and have no current diagnosis of substance dependence, you may be eligible to participate. We will use a method for stimulating the brain, called transcranial direct current stimulation (tDCS), to attempt to change the way you feel about your pain.

Wellness for 2  Mood Disorders
Study Type: Clinical
Study Ends On: Ongoing
The Wellness for 2 study is examining two types of programs in order to determine their effects on women who have experienced stress or sadness during their current pregnancy.