Newly Released Recommendations for Investigational Alzheimer’s Blood Tests Say They Have “Revolutionary Potential”

Stephen Salloway, MD, MS of Butler Hospital, Brown University
and Co-Author of the Recommendations Shares Insights on Future Potential


PROVIDENCE, RI, August 1, 2022 – Recommendations for the use of investigational Alzheimer’s “blood tests” were released yesterday at the Alzheimer’s Association International Conference® (AAIC®) and published in an article in Alzheimer’s & Dementia: Journal of the Alzheimer’s Association. The recommendations were made by a global workgroup convened by the Alzheimer’s Association which included leading Alzheimer’s disease researcher Stephen Salloway, MD, MS. Salloway is founder of the Memory and Aging Program at Butler Hospital and is also the Martin M. Zucker Professor of Psychiatry and Human Behavior, Professor of Neurology, and Associate Director of the Center for Alzheimer’s Disease Research at Brown University.

In the article, lead author Oskar Hansson, M.D., Ph.D., director of the Center for Neurodegenerative Diseases at Lund University and Skane University Hospital, Malmo, Sweden along with Salloway and other co-authors, state that although Alzheimer’s disease blood biomarkers (BBMs) are not yet ready for widespread use, they are important and valuable for current research trials as well as cautious initial use in specialized memory clinics, and may revolutionize the diagnosis of Alzheimer’s in the future.

“With additional study and evaluation, blood biomarkers truly could revolutionize the diagnosis of Alzheimer’s and other forms of dementia,” Dr. Salloway says. “In particular, they may prove to be an easy, inexpensive and relatively painless test for the disease that could be administered by primary care providers as part of routine physical exams. That’s extremely significant because it could potentially identify developing disease even decades before symptoms begin, allowing for early treatment that could delay the onset of symptoms and perhaps even reduce their severity when they do occur.”


Dr. Salloway says that further development and implementation of BBMs alongside further development of potential treatments for Alzheimer’s disease, could lead to an end to Alzheimer’s disease as we know it today.


“The more we learn from Alzheimer’s research, the more it has become clear that prevention and early intervention are the keys to defeating this disease,” Dr. Salloway says. “We’re likely decades away from having the knowledge and technology to try and reverse the disease once it has become advanced, if that ever becomes possible at all. But the ability to identify it in its earliest stages and develop disease-modifying drugs that prevent life-altering symptoms may be closer than we think.”


According to the workgroup, about 25-30% of patients with a clinical diagnosis of Alzheimer’s dementia are misdiagnosed when assessed at specialized dementia clinics, and the accuracy of clinical diagnosis is similar or even lower for other dementias, including frontotemporal dementia, dementia with Lewy bodies and vascular dementia. In fact, in most countries, most patients with cognitive or behavioral symptoms are managed in primary care where the misdiagnosis is even higher. The problem is especially acute in the earliest stages of the disease.


According to the article, BBMs show “great promise” — especially markers for Alzheimer’s-related brain changes related to nerve cell damage/death, and tau and beta amyloid accumulation (proteins in the brain believed to be related to the development of Alzheimer’s) — for “future use in both clinical practice and trials. However, few prospective studies have investigated the implementation of such BBMs in more heterogeneous populations.”


The workgroup points out that no studies have extensively evaluated BBMs for neurodegenerative

diseases in primary care, and calls for “well-performed BBM studies in diverse primary care

populations.” Such studies should also evaluate the impact of BBMs on diagnostic accuracy and change in patient management.


There are current uses for Alzheimer’s BBMs, however, the workgroup reported. For example, they

“recommend use of BBMs as (pre-)screeners to identify individuals likely to have Alzheimer’s

pathological changes for inclusion in trials evaluating disease-modifying therapies, provided Alzheimer’s status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing.”


BBMs can be used as exploratory outcomes in most clinical trials in Alzheimer’s and other

neurodegenerative dementias. In non-Alzheimer’s trials, BBMs can be used to identify patients who likely have Alzheimer’s-related brain changes, if that is a condition of exclusion from the study.


Full details of the workgroup’s recommendations are available in their article published in Alzheimer’s & Dementia: Journal of the Alzheimer’s Association, available online at



About the Memory and Aging Program at Butler Hospital

The Memory & Aging Program (MAP) at Butler Hospital is a worldwide leader in Alzheimer’s disease research and a local Rhode Island partner in the fight against Alzheimer’s and other forms of dementia. An affiliate of The Warren Alpert Medical School of Brown University, MAP has a 25-year history of excellence in Alzheimer’s clinical care, training, and research aimed at developing new and better ways to detect, treat, and someday even prevent Alzheimer’s. Individuals who wish to be considered for participation in current and future research studies and clinical trials conducted at the Memory and Aging Program for the prevention and treatment of Alzheimer’s disease can join the program’s Alzheimer’s Prevention Registry at Butler Hospital online at or by calling (401) 455-6402. For more information visit and follow on Facebook and Twitter.

About Butler Hospital

Butler Hospital, a member of Care New England, is the only private, nonprofit psychiatric and substance abuse hospital serving adults, seniors and adolescents in Rhode Island and southeastern New England. Founded in 1844, it was the first hospital in Rhode Island and has earned a reputation as the leading provider of innovative psychiatric treatments in the region. The Major Affiliated Teaching Hospital for Psychiatry and Behavioral Health at The Warren Alpert Medical School of Brown University, Butler is recognized worldwide as a pioneer in conducting cutting-edge research.