--- title: Prism Study for Depression description: This clinical trial investigates Prism treatment for people with Major Depressive Disorder (MDD) whose symptoms include loss of the ability to experience joy from things that were once pleasurable. image: https://www.butler.org/hubfs/-%20BUTLER/ButlerHospitalResearchStudy.jpg --- - [**Pay My Bill](https://www.carenewengland.org/pay/butler-hospital/) - [**Careers](https://www.butler.org/careers) - [**Donate](https://www.butler.org/ways-to-give) - [**My Chart](https://www.carenewengland.org/mychart) - [**+1 (844) 401-0111](tel:+1%20(844)%20401-0111) [![CNE Butler Behavioral Health](https://www.butler.org/hs-fs/hubfs/-%20CNE/CNE%20-%202026%20Branding/CNE%20Butler%20Behavioral%20Health.png?width=1200&height=475&name=CNE%20Butler%20Behavioral%20Health.png)](https://www.butler.org/) ** #### Site Search ** ** ![ # Prism Study for Depression ## **Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) with Anhedonia** ## **Purpose of the PRISM Study: ** The purpose of this research is to investigate a new non-drug treatment for depression called Prism. This clinical trial investigates Prism treatment for people with Major Depressive Disorder (MDD) whose symptoms include loss of the ability to experience joy from things that were once pleasurable. ## **The Study:** Prism provides a novel form of neurofeedback training and is delivered in our outpatient clinic at Butler Hospital; a similar version of this novel treatment recently received FDA approval for Post Traumatic Stress Disorder (PTSD). Participation in this randomized clinical trial includes two MRI brain scans, several assessment visits, and a series of Prism treatments (active or sham) in the Butler Hospital Neuromodulation Research Facility, all over 5 months; participants must remain on stable psychiatric medications during the time they are in the study. At the completion of participation in the study, all participants are eligible to receive a series of active (real) Prism treatments at no charge. ## **Eligibility:** - 22-75 years old - Diagnosis of Depression - Lack of or reduced interest in once enjoyable activities - Not feeling better after completing at least one prior antidepressant trial ## **Compensation:** Up to $1110.00 may be provided for time spent during the duration of the study ## **Contact Us:** ** **For interested participants, you may call [ (401) 680-4143 ](tel:+%20(401)680-4143)or reach out to the study team directly at [BRAIN@carene.org](mailto:BRAIN@carene.org) for additional information.     #### Contact Form To learn more about the study please contact our research team at [(401) 680-4143](tel:+401-680-4143) or complete the form below. **Organization** Butler Hospital **Recruitment Status** Open ##### Contact Us [Send Us A Message](https://www.butler.org/contact-us) [+1 (844) 401-0111](tel:+18444010111) 345 Blackstone Blvd, Providence, RI 02906 - [**](https://www.facebook.com/ButlerHospital) - [**](https://twitter.com/ButlerHospital) - [**](https://www.linkedin.com/company/butler-hospital/) ##### Other Care New England Locations [Care New England](https://www.carenewengland.org/) [Kent Hospital](https://www.kentri.org/) [The Providence Center](https://providencecenter.org/) [VNA of Care New England](https://www.vnacarenewengland.org/) [Women & Infants Hospital](https://www.womenandinfants.org/) ##### Patients and Visitors [Find A Provider](https://www.butler.org/provider-finder) [Integra Community Care](https://www.integracare.org/) ##### About Us [Who We Are](https://www.butler.org/about) [Diversity, Equity, & Inclusion (DEI)](https://www.carenewengland.org/dei) [Research](https://www.butler.org/research) [Legal Notices](https://www.carenewengland.org/legal-notices) [Auxiliary Aids & Services](https://www.carenewengland.org/auxiliary-aids-and-services) [Price Transparency](https://www.carenewengland.org/price-transparency) ##### Get Involved [Ways to Give](https://www.butler.org/ways-to-give) [Careers](https://www.carenewengland.org/careers) [Volunteer](https://www.carenewengland.org/volunteer) ##### News [In The News](https://www.butler.org/news) [Media Relations](https://www.butler.org/media-relations) --- Copyright © 2026 Care New England Health System × You are about to leave our website and enter an external site. We are not responsible for the content, privacy practices, or accuracy of information on the external site. Do you wish to continue? [Yes](https://www.butler.org/studies/prism-study-for-depression#yes)   [No](https://www.butler.org/studies/prism-study-for-depression#no)