Project THOUGHT

Study Information

Project THOUGHT is a research study funded by the National Institutes of Health. We are testing whether the excitement of specific brain regions can change cravings for opioids in individuals who recently started Suboxone. Participation in Project THOUGHT would involve the following: questionnaires and interviews, 7 visits to Butler Hospital in Providence, RI and 2 brain scans.

Contact Information

If you’re interested in participating, complete the form above or call the research team at (401) 680-4160. You will be asked a series of questions to determine if you meet criteria for eligibility. If eligible, research staff will arrange your study appointment.

Eligibility Criteria 

Participants must be between the ages of 21 and 50 and have started taking Suboxone within the last 30 days to be considered for the study.

Compensation/Reimbursement

Participants will receive up to $405 for completing all assessments.

More Information/FAQ

Who is eligible for the study?
Participants must be between the ages of 21 and 50 and have started taking Suboxone within the last 30 days to be onsidered for the study.

How much time is involved?
To determine if you are eligible, you will first have to conduct a screening questionnaire that takes approximately 15 minutes. If you meet study criteria, you will have two 45-minute baseline and follow-up interviews, two 1-hour MRI sessions, two 45-minute EEG sessions, and five 30 minute tDCS sessions.

How will you excite the brain?
Transcranial Direct Current Stimulation, or tDCS for short, is a noninvasive form of brain stimulation that involves a weak electrical current delivered through two electrodes that are placed on your head and held in place with an elastic net. Some participants will receive active tDCS, while others will receive a sham or placebo version of tDCS – this will be determined randomly, like the flip of a coin, and neither you nor the researchers will know which version you will receive.

What happens during the 7 visits to Butler?
5 of the visits to Butler involve 20-minute sessions of tDCS (described above). The 2 other visits happen before and after these 5 visits. These are the baseline (Visit 1) and Follow-up (Visit 7). At Visits 1 and 7, you will be asked to compete a series of questionnaires, computer tasks, and interviews with research staff. In addition, you will undergo an electroencephalography (EEG) recording of your brain activity. For the EEG procedure, a trained technician will apply a special cap to your head that records electrical signals on your scalp. During the recording, you will then sit quietly in a chair for a few minutes and then complete a 10-minute computer task while the EEG is recording your brain activity.

What is a brain scan?
Magnetic resonance imaging (MRI) of the body uses a powerful magnetic field, radio waves and a computer to produce detailed pictures of the inside of your body. A functional MRI (fMRI), which is what we will be using in Project THOUGHT, takes a picture of your brain working when you’re asked to do certain things.

What is the goal of this study?
The goal of Project THOUGHT is to determine if tDCS is effective at reducing cravings for opiates. We use your MRI and EEG scans BEFORE the five tDCS sessions, and then compare them to a set of MRI and EEG scans taken AFTER your tDCS sessions to see if there are any differences.

Is transportation provided?
Yes! If you do not have transportation, we will provide it for you in the form of a taxi.

Organization
Butler Hospital

Area of Study
Addiction

Recruitment Status
Open

Contact Form

If you’re interested in participating, complete the form below or call the research team at (401) 680-4160. You will be asked a series of questions to determine if you meet criteria for eligibility. If eligible, research staff will arrange your study appointment.