--- title: TRAILRUNNER-ALZ 3 description: Explore the TRAILRUNNER ALZ-3 Study, a global Phase 3 clinical trial evaluating Remternetug, an investigational monoclonal antibody targeting amyloid protein in early Alzheimer’s disease. image: https://www.butler.org/hubfs/-%20BUTLER/ButlerHospitalResearchStudy.jpg --- - [**Pay My Bill](https://www.carenewengland.org/pay/butler-hospital/) - [**Careers](https://www.butler.org/careers) - [**Donate](https://www.butler.org/ways-to-give) - [**My Chart](https://www.carenewengland.org/mychart) - [**+1 (844) 401-0111](tel:+1%20(844)%20401-0111) [![CNE Butler Behavioral Health](https://www.butler.org/hs-fs/hubfs/-%20CNE/CNE%20-%202026%20Branding/CNE%20Butler%20Behavioral%20Health.png?width=1200&height=475&name=CNE%20Butler%20Behavioral%20Health.png)](https://www.butler.org/) ** #### Site Search ** ** ![ # TRAILRUNNER-ALZ 3 # This study is now closed. --- # What is the TRAILRUNNER ALZ-3 Study? This is a 5 year, Phase 3, randomized, placebo-controlled, double-blind study enrolling approximately 1200 participants worldwide. This study involves an investigational medication, Remternetug, which is an IgG1 monoclonal antibody targeting amyloid protein. Eligible participants will be randomly assigned to one of two groups, one which receives the investigational medication and one that receives placebo. A placebo is an inactive substance that is designed to look like a medication. The investigational medication or the placebo will be administered by subcutaneous injection. The treatment phase of the study will last about 18 months, with an additional observation period to follow. What is the purpose of the TRAILRUNNER ALZ-3 ## What is the purpose of the TRAILRUNNER ALZ-3 Study? People with early Alzheimer’s disease (AD) may not have symptoms and may not have been diagnosed with Alzheimer’s disease. People with early AD may have an abnormal amount of amyloid protein in the brain that could increase the risk of developing memory and thinking problems in the future. If you participate in this study, you will have a blood test to check if you have this abnormal level of amyloid protein in your brain. The purpose of the TRAILRUNNER ALZ-3 Study is to evaluate the safety and efficacy of Remternetug in participants with early Alzheimer’s disease, and to learn whether Remternetug can delay the start or worsening of memory and thinking problems caused by AD. ## Eligibility  The participants in this study must be between the ages of 65-80 with no symptoms of Alzheimer’s disease. Participants must have a study partner, who has at least weekly contact with them, who can accompany them to some study visits. Interested participants can contact the Memory and Aging Program Outreach Team at [(401) 455-6402](tel:+(401)455-6402) or by sending an email to [memory@butler.org](mailto:memory@butler.org) to discuss additional eligibility criteria.   [Click here to subscribe to our monthly Memory Matters e-newsletter >>](https://www.butler.org/map-newsletter) **Organization** Butler Hospital **Area of Study** Memory and Aging **Status** Closed ##### Contact Us [Send Us A Message](https://www.butler.org/contact-us) [+1 (844) 401-0111](tel:+18444010111) 345 Blackstone Blvd, Providence, RI 02906 - [**](https://www.facebook.com/ButlerHospital) - [**](https://twitter.com/ButlerHospital) - [**](https://www.linkedin.com/company/butler-hospital/) ##### Other Care New England Locations [Care New England](https://www.carenewengland.org/) [Kent Hospital](https://www.kentri.org/) [The Providence Center](https://providencecenter.org/) [VNA of Care New England](https://www.vnacarenewengland.org/) [Women & Infants Hospital](https://www.womenandinfants.org/) ##### Patients and Visitors [Find A Provider](https://www.butler.org/provider-finder) [Integra Community Care](https://www.integracare.org/) ##### About Us [Who We Are](https://www.butler.org/about) [Diversity, Equity, & Inclusion (DEI)](https://www.carenewengland.org/dei) [Research](https://www.butler.org/research) [Legal Notices](https://www.carenewengland.org/legal-notices) [Auxiliary Aids & Services](https://www.carenewengland.org/auxiliary-aids-and-services) [Price Transparency](https://www.carenewengland.org/price-transparency) ##### Get Involved [Ways to Give](https://www.butler.org/ways-to-give) [Careers](https://www.carenewengland.org/careers) [Volunteer](https://www.carenewengland.org/volunteer) ##### News [In The News](https://www.butler.org/news) [Media Relations](https://www.butler.org/media-relations) --- Copyright © 2026 Care New England Health System × You are about to leave our website and enter an external site. We are not responsible for the content, privacy practices, or accuracy of information on the external site. Do you wish to continue? [Yes](https://www.butler.org/studies/trailrunner-alz-3#yes)   [No](https://www.butler.org/studies/trailrunner-alz-3#no)